Molecular mechanisms of nephroprotection by SGLT2 inhibitors: interaction between SIRT1 and hypoxia signaling in diabetic nephropathy

Molecular mechanisms of nephroprotection by SGLT2 inhibitors: interaction between SIRT1 and hypoxia signaling in diabetic nephropathy Italian Ministry of Education, University and Research Medical sciences » Medicine This project aims to investigate the molecular mechanisms underlying the nephroprotective effects of SGLT2 inhibition, with a focus on the role of the SIRT1/HIF-1α/HIF-2α signaling axis in diabetic nephropathy. The study will explore how empagliflozin (EMPA) modulates the balance between HIF-1α and...