Development of nucleic acid molecules aimed at recovering mitochondrial dysfunction in cancer and neurodegenerative diseases.

Development of nucleic acid molecules aimed at recovering mitochondrial dysfunction in cancer and neurodegenerative diseases. Italian Ministry of Education, University and Research Biological sciences The project aims to develop new therapeutic strategies based on targeting the mitochondrial protein VDAC in tumours and neurodegenerative diseases. The first objective is to interfere with the VDAC-Hexokinase-1 (HK1) complex, which plays a central role in both the mitochondrial dysfunction...